化学化工学院-刘锡建导师介绍

更新于 2024-12-09 导师主页
刘锡建 教授 硕士生导师
化学化工学院
化学工程与技术 ,药学 ,生物与医药
药理学,药剂学,生物医药材料,制药与精细化工
lxj9606@163.com; liuxijian@sues.edu.cn

l    2004.11-现在,    助教、讲师、副教授、教授,上海工程技术大学化学化工学院

l    2018.02-2019.02   新加坡南洋理工大学 材料工程与科学学院 访问学者(导师:陈晓东、俞璟)

l    2011.09-2015.03   东华大学 材料物理与化学 博士(导师:胡俊青)

l    2001.09-2004.06   北京化工大学 生物化工 硕士(导师:马润宇)

l    2000.08-2001.05   工程师,浙江新安化工集团

l    1996.09-2000.07   南昌大学 精细化工 本科                              

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科研项目

1.国家自然科学基金项目,21978165,模板介导药物纳米晶体精准组装的多尺度研究,2020/01-2023/12,62万元,在研,参与(第二)

2.国家自然科学基金项目,51472049,新型多功能半导体纳米光热转换材料的研制及其在癌症诊疗上的应用探索,2015/01-2018/12,已结题,主要完成人

3.横向项目,15(HG-002),高纯度的萝卜硫素的生产工艺的技术开发,2015/06-2015/09,已结题,主持

4.教育部科学技术研究重大项目,313015,高效空穴掺杂半导体Cu2-xSySe1-y光热材料的可控合成、表面改性剂生物应用,2013/01-2015/12,已结题,主要完成人

5. 横向项目,(20)HG-002,萝卜硫素的包埋工艺的开发及稳定性研究,2020/05-2021/10,已结题,主持

6. 横向项目,(22)HG-011,黑芥子酶产品的工艺开发,2022/06-2023/12,10万元,在研,主持

7. 上海市心脑血管非编码RNA成药性前沿科学研究基地(培育)开放课题,巨噬细胞膜包覆的纳米药物靶向抑制损伤血管内膜增生的研究,2023/01-2023/12,主持

8. 上海市Ⅲ类高峰学科-材料科学与工程开放课题,阶梯带隙ZnO异质材料的绿色制备及其光催化降解污染物应用研究,2023/04-2024/03,主持

9. 北京医学奖励基金会开放课题,肿瘤微环境响应缓释纳米硒复合材料及其在三阴性乳腺肿瘤诊疗中的应用,2023/06-2025/05,主持
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研究成果

1.    C. Ding, R. He, T. Cheng, J. Wang, X. Liu*, G. Guo*, Y. Chen*, Bacterial Outer Membrane‐Based Biomimetic Immune Adaptors: Mild Immunomodulatory and Bacterial Targeted Delivery Strategy Against Implant‐Related Infections, Advanced Functional Materials, 2023, 2304168. (IF= 19.0)

2.    X. Wang, C. Ding, Z. Zhang, C. Li, D. Cao, L. Zhao, G. Deng, Y. Luo, C. Yuan, J. Lu, X. Liu*, Degradable nanocatalyst enables antitumor/antibacterial therapy and promotion of wound healing for diabetes via self-enhanced cascading reaction, Chinese Chemical Letters, 2023, 34(7):107951. (IF= 9.1)

3.    Z. Zhang, J.Wang, Y. Luo*, C. Li, Y. Sun, K. Wang, G. Deng, L. Zhao, C Yuan, J. Lu, Y. Chen, J. Wan*, X. Liu*. The pH-responsive ZC-QPP hydrogel for synergistic antibacterial and antioxidant treatment to enhance wound healing. Journal of Materials Chemistry B, 2023, DOI: 10.1039/d3tb01567j.

4.    D. Cao, L. Chen, Z. Zhang, Y. Luo, L. Zhao, C. Yuan, J. Lu, X. Liu*, J. Li*, Biodegradable nanomaterials for diagnosis and therapy of tumors, Journal of Materials Chemistry B, 2023, 11(9):1829-1848. (IF= 7.0)

5.    S. Guan, X. Liu*, C. Li, X. Wang, D. Cao, J. Wang, L. Lin, J. Lu, G. Deng. J. Hu, Intracellular mutual amplification of oxidative stress and inhibition multidrug resistance for enhanced sonodynamic/chemodynamic/chemo therapy, Small, 2022,18(13): 2107160. (IF= 15.153, ESI高被引论文)

6.    X. Wang, C. Li, H. Jin, X. Wang, C. Ding, D. Cao, L. Zhao, G. Deng, J. Lu, Z. Wan*, X. Liu*, Mutual promotion of oxidative stress amplification and calcium overload by degradable spatially selective self-cascade catalyst for synergistic tumor therapy, Chemical Engineering Journal,2022, 432:134438. (IF= 16.744)

7.    S. Guan, X. Liu*, Y. Fu, C. Li, J. Wang, Q. Mei, G. Deng, W. Zheng, Z. Wan, J. Lu, A biodegradable “Nano-donut” for magnetic resonance imaging and enhanced chemo/photothermal/chemodynamic therapy through responsive catalysis in tumor microenvironment, Journal of Colloid and Interface Science, 2022, 608: 344-354. (IF= 9.965)

8.    N. Zheng, Y. Fu, X. Liu*, Z. Zhang, J. Wang, Q. Mei, X. Wang, G. Deng, J. Lu, J. Hu*, Tumor microenvironment responsive self-cascade catalysis for synergistic chemo/chemodynamic therapy by multifunctional biomimetic nanozymes, Journal of Materials Chemistry B, 2022,10(4): 637-645. (IF= 7.571)

9.    H. Zhao, R. Su, L. Teng, Q. Tian, F. Han, H. Li, Z. Cao, R. Xie, G. Li, X. Liu*, Z. Liu*, Recent advances in flexible and wearable sensors for monitoring chemical molecules, Nanoscale 2022, 14(5), 1653-1669. (IF= 8.307)

10.   N. Zheng, W. Kong, Z. Huang, X. Liu*, S. Liang*, G. Deng, L. Zhao, J. Lu, Novel theranostic nanoagent based on CuMo2S3-PEG-Gd for MRI-guided photothermal/photodynamic/chemodynamic therapy, Rare Metals, 2022,41(1):45-55. (IF= 6.318)

11.   J. Wang, W. Kong, H. Jin, C. Li, Q. Luo*, Y. Luo, C. Yuan, J. Lu, L. Zhang*, X. Liu*. Tumor microenvironment responsive theranostic agent for enhanced chemo/chemodynamic/photothermal therapy. Colloids and Surfaces B: Biointerfaces, 2022, 218: 112750. (IF= 5.999)

12.   X. Wang, Z. Wan, C. Li, X. Meng, L. Zhao, J. Lu, J. Qian*, X. Liu*. Defective Cu2-xSe crystals for ultrasound-enhanced CDT of tumor therapy. Ceramics International, 2022,48:34564–34570.  (IF= 5.532)

13.   Z. Zhang, J. Wang,W. Xia,D. Cao,X. Wang,Y. Kuang,Y. Luo,C. Yuan, J. Lu, X. Liu*. Application of Hydrogels as Carrier in Tumor Therapy: A Review. Chemistry-An Asian Journal, 2022,17(22): e202200740. (IF= 4.839)

14.   N. Zheng, Q. Wang, C. Li, X. Wang, X. Liu*, X. Wang, G. Deng, J. Wang, L. Zhao and J. Lu, Responsive degradable theranostic agents enable controlled selenium delivery to enhance photothermal radiotherapy and reduce side effects. Advanced Healthcare Materials, 2021,10,202002024. (IF= 11.092)

15.   C. Ding, C. Yang, T. Cheng, X. Wang, Q. Wang, R. He, S. Sang, K. Zhu, D. Xu, J. Wang*, X. Liu*, X. Zhang*, Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis, Journal of Nanobiotechnology, 2021,19(1):382. (IF= 9.429)

16.   H. Zhao, J. Wang, X. Li, Y. Li, C. Li, X. Wang, J. Wang, S. Guan, Y. Xu*, G. Deng, Y. Chen*, J. Lu, X. Liu*, A biocompatible theranostic agent based on stable bismuth nanoparticles for X-ray computed tomography/magnetic resonance imaging-guided enhanced chemo/photothermal/chemodynamic therapy for tumours, Journal of Colloid and Interface Science, 2021,604,80-90. IF= 9.965)

17.   X. Liu*, Y. Jiang, P. Cai, R. Gao, Editorial: Advanced Silica Nanomaterials for Drug Delivery, Frontiers in Chemistry 2021,9: 677647. (IF= 5.545)

18.   M. Zhang, X. Liu*, Q. Luo, Q. Wang, L. Zhao, G. Deng, R. Ge, L. Zhang*, J. Hu, and J. Lu*. Tumor environment responsive degradable CuS@mSiO2@MnO2/DOX for MRI guided synergistic chemo-photothermal therapy and chemodynamic therapy. Chemical Engineering Journal, 2020, 389:124450. (IF= 16.744, ESI高被引论文)

19.   X. Liu*, M. Zhang, D. Yan, G. Deng, Q. Wang, C. Li, L. Zhao and J. Lu*, A smart theranostic agent based on Fe-HPPy@Au/DOX for CT imaging and PTT/chemotherapy/CDT combined anticancer therapy. Biomaterials Science, 2020, 8: 4067-4072. (IF= 7.590)

20.   X. Liu, J. Liu, J. Wang, T. Wang, Y. Jiang, J. Hu, Z. Liu*, X. Chen*, and J. Yu*. Bioinspired, Microstructured Silk Fibroin Adhesives for Flexible Skin Sensors. ACS Applied Materials & Interfaces, 2020, 12 (5): 5601-5609. (IF= 10.383)

21.   W. Kong, Q. Wang, G. Deng, H. Zhao, L. Zhao, J. Lu*, and X. Liu*. Se@SiO2@Au-PEG/DOX NCs as a multifunctional theranostic agent efficiently protect normal cells from oxidative damage during photothermal therapy. Dalton Transactions, 2020, 49 (7): 2209-2217. (IF= 4.569)

22.   X. Wang, X. Liu*, C. Xiao, H. Zhao, M. Zhang, N. Zheng, W. Kong, L. Zhang, H. Yuan, L. Zhang, and J. Lu*. Triethylenetetramine-modified hollow Fe3O4/SiO2/chitosan magnetic nanocomposites for removal of Cr(VI) ions with high adsorption capacity and rapid rate. Microporous and Mesoporous Materials, 2020, 297,110041. (IF= 5.876)

23.   L. Ren, X. Liu*, T. Ji, G. Deng, F. Liu, H. Yuan, J. Yu, J. Hu, and J. Lu*. All-in-One Theranostic Agent with Seven Functions Based on Bi-Doped Metal Chalcogenide Nanoflowers. ACS Applied Materials & Interfaces, 2019, 11: 45467-45478. (IF= 10.383)

24.   L. Zhang, X. Liu*, M. Zhang, H. Yuan, L. Zhang, J. Lu*, Facile construction of dual functional Fe3O4@C-MoO2-Ni composites for catalysis and adsorption. Applied Surface Science, 2019, 494:783-794. (IF= 7.392)

25.   B. Yang, G. Deng, R. Zhao, C. Dai, C. Jiang, X. Wang, Y. Jing, X. Liu*, S. Xia*, B. Han*. Porous Se@SiO2 nanosphere-coated catheter accelerates prostatic urethra wound healing by modulating macrophage polarization through reactive oxygen species-NF-jB pathway inhibition. Acta Biomaterialia, 2019,88: 392-405. (IF= 10.633)

26.   Y. Wang, X. Liu*, G. Deng, J. Sun, H. Yuan, Q. Li, Q. Wang, and J. Lu*. Se@SiO2-FA-CuS Nanocomposites for Targeted Delivery of DOX and Nano Selenium in Synergistic Combination of Chemo-photothermal Therapy. Nanoscale, 2018, 10:2866–2875 (IF= 8.307, ESI高被引论文)

27.   G. Ma, X. Liu*, G. Deng, H. Yuan, Q. Wang, and J. Lu*. A novel theranostic agent based on porous bismuth nanosphere for CT imaging-guided combined chemo-photothermal therapy and radiotherapy. Journal of Materials Chemistry B, 2018, 6: 6788-6795. (IF= 7.571)

28.   D. Yan, X. Liu*, G. Deng, H. Yuan, Q. Wang, L. Zhang, and J. Lu*. Facile assembling of novel polypyrrole nanocomposites theranostic agent for magnetic resonance and computed tomography imaging guided efficient photothermal ablation of tumors. Journal of Colloid and Interface Science, 2018, 530: 547-555(IF= 9.965).

29.   Z. Huang, X. Liu*, G. Deng, H. Yuan, Q. Wang, L. Zhang, and J. Lu*. One-step assembly of CuMo2S3 nanocrystals for the synergistic effect of photothermal therapy and photodynamic therapy. Dalton Transactions, 2018, 47 (16): 5622-5629. (IF= 4.569)

30.   X. Liu*,Y. Wang,Q.Yu, G. Deng, Q. Wang, X. Ma, Q. Wang, and J. Lu*. Selenium nanocomposites as multifunctional nanoplatform for imaging guiding synergistic chemo-photothermal therapy. Colloids and Surfaces B: Biointerfaces, 2018, 166:161–169(IF= 5.999)

31.   Y. Wang, X. Liu*, G. Deng, Q. Wang, L. Zhang, Q. Wang, and J. Lu*. Multifunctional PS@CS@Au-Fe3O4-FA nanocomposites for CT, MR and fluorescence imaging guided targeted-photothermal therapy of cancer cells. Journal of Materials Chemistry B, 2017,5(22): 4221-4232.( IF= 5.344)

32.   L. Ren, X. Liu*, Q. Wang, L. Zhang, G. Deng, F. Zhou, and J. Lu*. Facile fabrication of a magnetically smart PTX-loaded Cys-Fe3O4/CuS@BSA nano-drug for imaging-guided chemo-photothermal therapy. Dalton Transactions, 2017, 46 (7): 2204-2213. (IF=4.174)

33.   C. Xiao, X. Liu*, S. Mao, L. Zhang, and J. Lu*. Sub-micron-sized polyethylenimine-modified polystyrene/Fe3O4/chitosan magnetic composites for the efficient and recyclable adsorption of Cu(II) ions. Applied Surface Science, 2017, 394: 378-385.(IF= 6.182)

34.   X. Liu*, G. Deng, Y. Wang, Q. Wang, Z. Gao,Y. Sun, W. Zhang, J. Lu* and J. Hu A novel and facile synthesis of porous SiO2-coated ultrasmall Se particles as a drug delivery nanoplatform for efficient synergistic treatment of cancer cells. Nanoscale, 2016, 8:8536-8541. (IF= 6.895)

35.   Z. Gao, X. Liu*, G. Deng, F. Zhou, Q. Wang, L. Zhang, and J. Lu*. Facile one-pot synthesis of Fe3O4@chitosan nanospheres for MRI and fluorescence imaging guided chemo-photothermal combinational cancer therapy. Dalton Transactions, 2016, 45 (48): 19519–19528. (IF= 4.174)

36.   Z. Gao, X. Liu*, G. Deng, F. Zhou, L. Zhang, Q. Wang, and J. Lu*. Fe3O4@mSiO2-FA-CuS-PEG nanocomposites for magnetic resonance imaging and targeted chemo-photothermal synergistic therapy of cancer cells. Dalton Transactions, 2016, 45 (34): 13456-13465. (IF= 4.174)

37.   X. Liu, Y. Sun, Y. Wang, L. Zhang, and J. Lu*. Synthesis and photocatalytic activities of Nd-doped TiO2 mesoporous microspheres. Functional Materials Letters, 2016, 9 (1): 1650013.( IF= 2.0)

38.   J. Sun, X. Liu*, Z. Fang, S. Mao, L. Zhang, S. Rohani, and J. Lu*. Solubility Measurement and Simulation of Rivaroxaban (Form I) in Solvent Mixtures from 273.15 to 323.15 K. Journal of Chemical and Engineering Data, 2016, 61 (1): 495-503. (IF= 2.369)

39.   Z. Fang, X. Liu*, M. Zhang, J. Sun, S. Mao, J. Lu*, and S. Rohani. A neural network approach to simulating the dynamic extraction process of L-phenylalanine from sodium chloride aqueous solutions by emulsion liquid membrane. Chemical Engineering Research & Design, 2016, 105: 188-199. (IF= 3.35)

40.   X. Liu, Q. Ren, F. Fu, R. Zou, Q. Wang, G. Xin, Z. Xiao, X. Huang, Q. Liu, and J. Hu*. CuS@mSiO2-PEG core-shell nanoparticles as a NIR light responsive drug delivery nanoplatform for efficient chemo-photothermal therapy. Dalton Transactions, 2015, 44 (22): 10343-10351. (IF= 4.174)

41.   X. Liu, J. Zhao, Y. Cao, W. Li, Y. Sun, J. Lu, Y. Men, and J. Hu. Facile synthesis of 3D flower-like porous NiO architectures with an excellent capacitance performance. Rsc Advance, 2015, 5 (59): 47506-47510. (IF= 3.119)

42.   L. Cai, Y. Sun*, W. Li, W. Zhang, X. Liu*, D. Ding and N. Xu. CuS hierarchical hollow microcubes with improved visible-light photocatalytic performance. Rsc Advance, 2015,5:98136-98143. (IF= 3.119)

43.   X. Liu, F. Fu, K. Xu, R. Zou, J. Yang, Q. Wang, Q. Liu, Z. Xiao, and J. Hu*. Folic acid-conjugated hollow mesoporous silica/CuS nanocomposites as a difunctional nanoplatform for targeted chemo-photothermal therapy of cancer cells. Journal of Materials Chemistry B, 2014, 2 (33): 5358-5367. (IF= 5.344)

44.   X. Liu, B. Li, F. Fu, K. Xu, R. Zou, Q. Wang, B. Zhang, Z. Chen, and J. Hu*. Facile synthesis of biocompatible cysteine-coated CuS nanoparticles with high photothermal conversion efficiency for cancer therapy. Dalton Transactions, 2014, 43 (30): 11709-11715. (IF= 4.174)

45.   X. Liu, Q. Wang, C. Li, R. Zou, B. Li, G. Song, K. Xu, Y. Zheng, and J. Hu*. Cu2-xSe@mSiO2-PEG core-shell nanoparticles: a low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density. Nanoscale, 2014, 6 (8): 4361-4370. (,IF= 6.895)

 

授权专利


1.刘锡建,王香,张子文,陆杰. 一种壳聚糖/二氧化锰/葡萄糖氧化酶纳米复合材料及其制备和应用[P].ZL 2022104373602,2022-04-19

2.刘锡建,管少琪,王星妍,王金霞,张子文,曹东苗,王香,陆杰. 一种含锌的金属有机框架包覆二氧化锰纳米复合材料及其制备和应用[P].ZL2021110970536, 2021-09-18

3.张旻昳,刘锡建,孔文艳,郑喃喃,赵行,王香,管少琪,陆杰. 硫化铜/二氧化硅/二氧化锰纳米复合粒子及制法和应用[P].ZL2020100775072, 2020-01-30

4.刘儒华,刘锡建. 一种萝卜硫素的油悬液及其制备方法[P].ZL2022104938947, 2022-04-28

5.刘锡建,张旻昳,王星妍,王金霞,张子文,曹东苗,陆杰. 金属硫化掺杂的介孔二氧化硅纳米复合粒子及其制备和应用[P]. ZL2021104593203,2021-04-27

6.王香,刘锡建,王星妍,王金霞,管少琪,赵行,曹东苗,张子文,朱同贺,陆杰. CaO2/MnFe2O4纳米复合材料及其制备和应用[P]. ZL2021103782871,2021-04-08

7.管少琪,刘锡建,王星妍,王金霞,张子文,曹东苗,陆杰. 一种掺杂铜、锰的类普鲁士蓝-二硫化钼纳米复合材料及其制备和应用[P]. ZL2021108624037,2021-07-29

8.刘锡建,赵行,王星妍,王金霞,王香,管少琪,朱同贺,陆杰. 一种铋/二氧化硅/二氧化锰/阿霉素复合材料及其制备和应用[P]. ZL2021105543108,2021-05-20

9.刘锡建,任兰芳,陆杰. 铋掺杂的金属硫化物纳米花及其制备方法[P]. ZL201910349442X, 2019-04-28

10.刘锡建,陆杰,王烨颖,任兰芳,邓国英,王谦,周峰. 一种金包覆硒化铜纳米粒子及其制备方法与应用[P]. ZL2016105572129, 2016-07-15

11.马国昌,刘锡建,袁海宽,陆杰. 一种多孔铋纳米微球及其制备方法和应用[P]. ZL2018110080142, 2018-08-31

12.王烨颖,刘锡建,陆杰. 一种偶联叶酸靶向的纳米复合粒子及其制备方法与应用[P]. ZL2017100924342, 2017-02-21

13.高志方,刘锡建,王烨颖,王帆,任兰芳,陆杰. 偶联叶酸靶向的四氧化三铁/介孔二氧化硅/硫化铜纳米复合粒子及其制备方法和应用[P]. ZL2016102505334, 2016-04-21

14.刘锡建.一种高含量的胭脂虫红色素纯化的方法[P]. ZL2019113120343, 2019-12-18

15.刘锡建,陆杰,孙彦刚,张丽娟,张红,徐菁利. 一种多孔Se-SiO2纳米粒子及其制备方法和应用[P].ZL2015104961731, 2015-08-13

16.刘锡建,肖稳发,王远强,孙彦刚,徐菁利,超级电容器电极材料钴镍氧化物复合材料的制备方法,ZL2013104761789[P]. 2016-04-27.

17.刘锡建,肖稳发,王远强,孙彦刚,徐菁利,一种超级电容器电极材料氧化镍的制备方法,ZL2013104761628[P]. 2014-12-03.

18.胡俊青,刘锡建,邹儒佳,王滕,安磊,王谦,徐开兵,宋国胜,一种硒化铜/介孔二氧化硅核壳纳米粒子及其制备方法和应用, ZL2013104821741[P]. 2015-06-03.

19.刘锡建,肖稳发,王远强,谷里鹏,李荣秋,李健,蒋文斌,谢燕婷,一种胭脂虫红色素树脂纯化的方法,ZL201210240064X[P]. 2015-08-05.

20.刘儒华,刘锡建. 一种萝卜硫素的纯化方法, ZL 2015103340813[P].2015-06-16.

21.刘儒华,刘锡建,翁行忠. 一种不含铝盐的胭脂虫红色淀及其制备方法[P]. ZL2020115731062,2020-12-24

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学校介绍


    上海工程技术大学是一所工程技术、经济管理、艺术设计等多学科互相渗透、协调发展的全日制普通高等学校。我校现有机械工程学院、电子电气工程学院、管理学院、化学化工学院、材料工程学院、汽车工程学院、艺术设计学院、航空运输学院、服装学院、基础教学学院、社会科学教学部、体育教学部等15个院、部;上海市汽车工程实训中心、计算中心、工程实训中心、艺术设计展示中心、服装设计展示中心5个设备先进的教学实训基地;能源与环境工程研究所、激光工业技术研究所、经济研究所、化工研究所、劳动关系研究中心5个科研机构。学校坚持依托产业办学,产学研紧密结合,主动为上海经济建设发展服务的办学方向,致力于培养具有创新精神和实践能力的高素质、综合型人才,形成了具有发展潜力的办学特色。
    经过二十五年不懈努力,学校的科研、教学成果显著,办学规模逐步扩大,办学水平不断提高,教学质量稳步上升。我校的载用工具运用工程学科、服装设计与工程学科、公共艺术学科是上海市第四期重点培育学科,我校的学科建设力度不断加大,办学层次不断提高。

    随着学校整体实力不断加强,与国外高等院校的交流日益发展,我校开展了与澳大利亚、日本、德国、加拿大等著名大学进行学者互访、学术交流和合作教育等活动。先后与法国、美国、韩国等著名大学开展合作办学,现有中法合作服装设计与工程专业、中美合作机械设计制造及其自动化(汽车工程)专业、中美合作交通运输(汽车运用技术)专业、中韩合作艺术设计(多媒体设计)专业。

    根据市委、市府统一部署,学校将整体迁入松江大学园区,2003级学生全部进入松江大学园区。

    目前学校正面临新的发展机遇,全校教职工必将在市委、市政府的领导下和社会各界的关心支持下,团结一致、振奋精神、开拓进取、乘胜前进,为把上海工程技术大学建设成为一所具有时代特色、多学科的现代化大学而不懈努力!

 

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