研究方向：基于多组学技术的天然药物和中药复方药效物质基础及作用机制研究

科研项目：

l  国家自然科学基金青年科学基金项目（31701032），肠道菌群调控高脂饮食代谢适应的分子机制研究，2018/01-2020/12，结题, 主持

l  上海市教育委员会，人工智能促进科研范式改革 赋能学科跃升计划项目（重点项目），人工智能在抗细菌耐药性天然药物内应分子和作用靶点发现中的应用, 2024/01-2025/12，在研，主持

l  上海雷允上药业有限公司，关节镇痛巴布膏治疗退行性骨关节炎的物质基础及作用机制研究，2023/03-2024/12，在研，主持

l  上海市肺科医院，补肾调元通络方协同PD-1抑制剂联合化疗治疗晚期肺鳞癌随机对照的临床研究，2024/08-2025/07，在研，主持

l  赣州华汉生物科技有限公司，含西兰花种子提取物的复合型微生态健康产品的开发及应用，2024/08-2029/07，在研，主持

l  国家自然科学基金面上项目（81973453）, 中药苦参抗HER2阳性乳腺癌有效成分群及其 PI3K/AKT/P27分子机制研究, 结题, 参与

l  国家国际科技合作专项项目（2014DFA31870），中国人2型糖尿病的分子分型及疾病早期预警中的作用，结题，参与

l  雀巢健康科学研究所合作项目 (B007184-00002), Microbiome Metabonomics: monitoring mammalian - gut microbial co-metabolism in human plasma, urine and stools，结题，参与

[1] Zhu J, Liu Q, Nie S, Huang Y, Zhao L*, Mo F*. LEPR/FOS/JUNB signaling pathway contributes to chronic restraint stress-induced tumor proliferation. Biochem Biophys Res Commun. 2024, 719:150042. （SCIIF 3.10）

[2] Xie Y, Li H*, Liu D, Zhao L, Liu X, Liu X, Li Y. Novel Sulfoximine Derivatives Containing Cyanoguanidine and Nitroguanidine Moieties: Design, Synthesis, and Bioactivities. J Agric Food Chem. 2024,72(20):11716-11723. （SCIIF 6.10）

[3] Gu K, Feng S, Zhang X, Peng Y, Sun P, Liu W, Wu Y, Yu Y, Liu X, Liu X, Deng G, Zheng J, Li B, Zhao L*. Deciphering the antifungal mechanism and functional components of cinnamomum cassia essential oil against Candida albicans through integration of network-based metabolomics and pharmacology, the greedy algorithm, and molecular docking. J Ethnopharmacol. 2024, 319(Pt 2):117156（SCIIF 5.20）

[4] Zhang Z, Wang J, Luo Y, Li C, Sun Y, Wang K, Deng G, Zhao L, Yuan C, Lu J, Chen Y, Wan J, Liu X*. A pH-responsive ZC-QPP hydrogel for synergistic antibacterial and antioxidant treatment to enhance wound healing. J Mater Chem B. 2023, 11(38):9300-9310. （SCIIF 7.57）

[5] Cao D, Chen L, Zhang Z, Luo Y, Zhao L, Yuan C, Lu J, Liu X*, Li J*. Biodegradable nanomaterials for diagnosis and therapy of tumors. J Mater Chem B. 2023,11(9):1829-1848. （SCIIF 7.57）

[6] Zhao W, Yang C, Zhang N, Peng Y, Ma Y, Gu K, Liu X, Liu X, Liu X, Liu Y, Li S*, Zhao L*. Menthone Exerts its Antimicrobial Activity Against Methicillin Resistant Staphylococcus aureus by Affecting Cell Membrane Properties and Lipid Profile. Drug Des Devel Ther. 2023,17:219-236. （SCIIF 4.32）

[7] Liu Y, Li H*, Zhao Y, Xie Y, He Y, Qin Y, Wang Y, Shi J, Zhao L, Li Y, Zheng W. Design, synthesis, and antifungal activities of novel sulfoximine derivatives for plant protection. Pest Manag Sci. 2023,79(4):1273-1283. (SCIIF 4.46)

[8] Zhang N, Peng Y, Zhao L*, He P, Zhu J, Liu Y, Liu X, Liu X, Deng G, Zhang Z, Feng M. Integrated Analysis of Gut Microbiome and Lipid Metabolism in Mice Infected with Carbapenem-Resistant Enterobacteriaceae. Metabolites. 2022,12(10):892. (SCIIF 5.581)

[9] Huang J, Zhao L*, Sun J, Wang L, Gu J, Liu X, Yang M, Wang Y, Zhang N, Zhu J, Xu S, Ren X, Su Y*. Clinical Evidence and Potential Mechanisms of Complementary Treatment of Ling Gui Zhu Gan Formula for the Management of Serum Lipids and Obesity. Evid Based Complement Alternat Med. 2022:7714034. (SCIIF 2.650)

[10] Hao F, Zhu J, Zhang N, He P, Miao Q, Liu Y, Gao Y, Liu X, Deng G, Zhang Z, Feng M*, Zhao L*. Association between gut microbiome and metabolome in mice suffering from acute carbapenem-resistant Escherichia coli infection. J Pharm Biomed Anal. 2022,215:114770. (SCIIF 3.57)

[11] Wang X, Wan Z, Li C, Meng X, Zhao L, Lu J, Qian J*, Liu X*. Defective Cu2-xSe crystals for ultrasound-enhanced CDT of tumor therapy. Ceram Int, 2022, 48(23): 34564-34570. (SCIIF 5.53)

[12] Wang X,  Li C, Jin H, Wang X, Ding C , Cao D, Zhao  L, Deng G, Lu J,  Wan Z*, Liu X*. Mutual promotion of oxidative stress amplification and calcium overload by degradable spatially selective self-cascade catalyst for synergistic tumor therapy. Chem Eng J, 2022,432:134438. (SCIIF 16.74)

[13] Xiao Y, Li H*, Shao Q, Liu Y, Xie Y, Zhao L, Li Y. Design, Synthesis, and Antifungal Activity of Sulfoximine Derivatives Containing Nitroguanidine Moieties. Chem Biodivers. 2022,19(3):e202100839. (SCIIF 2.75)

[14] Zheng N, Kong W, Huang Z, Liu X*, Liang S*, Deng G, Zhao L, Lu J.  Novel theranostic nanoagent based on CuMo2S3-PEG-Gd for MRI-guided photothermal/photodynamic/ chemodynamic therapy. Rare Met. 2022,41, 45–55.  (SCIIF 6.32)

[15] 孙培培,张宁,赵琳静*,等.亚抑菌浓度肉桂挥发油暴露对白色念珠菌脂质稳态的影响[J].分析化学,2022,50(01):92-107. (SCIIF=1.19)

[16] Zheng M, Wang R, Chen S, Zou Y, Yan L*, Zhao L*, Li X*. Design, Synthesis and Antifungal Activity of Stapled Aurein1.2 Peptides. Antibiotics (Basel). 2021,10(8):956. (SCIIF 5.22)

[17] Zheng N, Wang Q, Li C, Wang X, Liu X*, Wang X, Deng G, Wang J, Zhao L, Lu J. Responsive Degradable Theranostic Agents Enable Controlled Selenium Delivery to Enhance Photothermal Radiotherapy and Reduce Side Effects. Adv Healthc Mater. 2021 ,10(10):e2002024 (SCIIF 11.09)

[18] Liu X*, Zhang M , Yan D , Deng G , Wang Q , Li C , Zhao L , Lu J* . A smart theranostic agent based on Fe-HPPy@Au/DOX for CT imaging and PTT/chemotherapy/CDT combined anticancer therapy. Biomater Sci. 2020,8(15):4067-4072. (SCIIF 7.59)

[19] Miao Q, Zhao L*, Wang Y, Hao F, Sun P, He P, Liu Y, Huang J, Liu X, Liu X, Deng G, Li H, Li L, Tang Y, Wang L, Feng M*, Jia W. Microbial metabolomics and network analysis reveal fungistatic effect of basil (Ocimum basilicum) oil on Candida albicans. J Ethnopharmacol. 2020,260:113002. (SCIIF 5.20)

[20] Zhao L, Hao F, Huang J, Liu X, Ma X, Wang C, Bao Y, Wang L, Jia W, Zhao A, Jia W*. Sex- and Age-Related Metabolic Characteristics of Serum Free Fatty Acids in Healthy Chinese Adults. J Proteome Res. 2020,19(4):1383-1391. (SCIIF 5.37)

[21] Zhang M, Liu X*, Luo Q , Wang Q , Zhao L, Deng G, Ge R, Zhang L*, Hu J, Lu J. Tumor environment responsive degradable CuS@mSiO2@MnO2/DOX for MRI guided synergistic chemo-photothermal therapy and chemodynamic therapy. Chem Eng J. 2020,389: 124450 (SCIIF 16.74)

[22] Kong W, Wang Q, Deng G, Zhao H, Zhao L, Lu J*, Liu X*. Se@SiO₂@Au-PEG/DOX NCs as a multifunctional theranostic agent efficiently protect normal cells from oxidative damage during photothermal therapy. Dalton Trans. 2020,49(7):2209-2217.( SCIIF 4.57)

[23] Zhao L, Ni Y, Su M, Li H, Dong F, Chen W, Wei R, Zhang L, Guiraud SP, Martin FP, Rajani C, Xie G, Jia W*. High Throughput and Quantitative Measurement of Microbial Metabolome by Gas Chromatography/Mass Spectrometry Using Automated Alkyl Chloroformate Derivatization. Anal Chem. 2017,89(10):5565-5577. (SCIIF 8.01)

[24] Zhao L, Ni Y, Yu H, Zhang P, Zhao A, Bao Y, Liu J, Chen T, Xie G, Panee J, Chen W, Rajani C, Wei R, Su M, Jia W*, Jia W*. Serum stearic acid/palmitic acid ratio as a potential predictor of diabetes remission after Roux-en-Y gastric bypass in obesity. FASEB J. 2017,31(4):1449-1460. (SCIIF 5.83)

[25] Chen WL, Wang YY, Zhao A, Xia L, Xie G, Su M, Zhao L, Liu J, Qu C, Wei R, Rajani C, Ni Y, Cheng Z, Chen Z*, Chen S*, Jia W*. Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential. Cancer Cell. 2016,30(5):779-791. (SCIIF 38.59)

[26] Zhao L, Ni Y, Ma X, Zhao A, Bao Y, Liu J, Chen T, Xie G, Panee J, Su M, Yu H, Wang C, Hu C, Jia W*, Jia W*. A panel of free fatty acid ratios to predict the development of metabolic abnormalities in healthy obese individuals. Sci Rep. 2016,6:28418. (SCIIF 5.00)

[27] Zhao L, Zhao A, Chen T, Chen W, Liu J, Wei R, Su J, Tang X, Liu K, Zhang R, Xie G, Panee J, Qiu M, Jia W*. Global and Targeted Metabolomics Evidence of the Protective Effect of Chinese Patent Medicine Jinkui Shenqi Pill on Adrenal Insufficiency after Acute Glucocorticoid Withdrawal in Rats. J Proteome Res. 2016,15(7):2327-36. (SCIIF 5.37)

[28] Ni Y, Zhao L (Co-first), Yu H, Ma X, Bao Y, Rajani C, Loo LW, Shvetsov YB, Yu H, Chen T, Zhang Y, Wang C, Hu C, Su M, Xie G, Zhao A, Jia W*, Jia W*. Circulating Unsaturated Fatty Acids Delineate the Metabolic Status of Obese Individuals. EBioMedicine. 2015,2(10):1513-22. (SCIIF 11.21)

[29] Zhao L, Wu H, Zhao A, Lu H, Sun W, Ma C, Yang Y, Xin X, Zou H, Qiu M*, Jia W*. The in vivo and in vitro study of polysaccharides from a two-herb formula on ulcerative colitis and potential mechanism of action. J Ethnopharmacol. 2014,153(1):151-9. (SCIIF 5.20)

[30] Zhao L, Wu H, Qiu M, Sun W, Wei R, Zheng X, Yang Y, Xin X, Zou H, Chen T, Liu J, Lu L, Su J, Ma C, Zhao A*, Jia W*. Metabolic Signatures of Kidney Yang Deficiency Syndrome and Protective Effects of Two Herbal Extracts in Rats Using GC/TOF MS. Evid Based Complement Alternat Med. 2013:540957. (SCIIF 2.65)

[31] Tan B, Qiu Y, Zou X, Chen T, Xie G, Cheng Y, Dong T, Zhao L, Feng B, Hu X, Xu LX, Zhao A, Zhang M, Cai G, Cai S, Zhou Z, Zheng M, Zhang Y, Jia W*. Metabonomics identifies serum metabolite markers of colorectal cancer. J Proteome Res. 2013,12(6):3000-9. (SCIIF 5.37)

[32] Zheng X, Zhao A, Xie G, Chi Y, Zhao L, Li H, Wang C, Bao Y, Jia W, Luther M, Su M, Nicholson JK, Jia W*. Melamine-induced renal toxicity is mediated by the gut microbiota. Sci Transl Med. 2013,5(172):172ra22. (SCIIF 19.32)

[33] Zhou M, Wang S, Zhao A, Wang K, Fan Z, Yang H, Liao W, Bao S, Zhao L, Zhang Y, Yang Y, Qiu Y, Xie G, Li H, Jia W*. Transcriptomic and metabonomic profiling reveal synergistic effects of quercetin and resveratrol supplementation in high fat diet fed mice. J Proteome Res. 2012,11(10):4961-71. (SCIIF 5.37)

[34] Xie G, Zhao A, Zhao L, Chen T, Chen H, Qi X, Zheng X, Ni Y, Cheng Y, Lan K, Yao C, Qiu M, Jia W*. Metabolic fate of tea polyphenols in humans. J Proteome Res. 2012,11(6):3449-57. (SCIIF 5.37)

[35] Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y*, Jia W*. Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012,11(2):1354-63. (SCIIF 5.37)

[36] Zheng X, Xie G, Zhao A, Zhao L, Yao C, Chiu NH, Zhou Z, Bao Y, Jia W, Nicholson JK, Jia W*. The footprints of gut microbial-mammalian co-metabolism. J Proteome Res. 2011,10(12):5512-22. (SCIIF 5.37)

[37] Zhao L, He H, Shi M*, Toy P*. Polystyrene-supported phosphine-catalyzed aza-Baylis-Hillman reactions and the relationship between resin loading level and catalyst efficiency. J Comb Chem. 2004,6(5):680-3. (SCIIF 4.197)

[38] Zhao L, Kwong C, Shi M*, Toy P*. Optimization of Polystyrene-Supported Triphenylphosphine Catalysts for Aza-Morita-Baylis-Hillman Reactions. Tetrahedron. 2005, 61(51), 12026-12032. （IF=2.641）

[39] Shao L, Zhao L, Shi M*. Dihalogenation of gem-Aryl Disubstituted Methylenecyclopropanes by DEAD or DIAD/TiX4 or Free Halogen. Eur J Org Chem. 2004,23:4894-4900. (IF=3.261)

[40] 翟亚森,刘晓会*,杨天波,高瑾,胡文毅,武艺,彭媛媛,赵琳静*.鱼腥草挥发油抗大肠埃希菌的活性成分和机制研究[J].食品与发酵工业,2024.

[41] 王玉婷,彭媛媛,刘霞,陈雪琴,赵琳静*.不同提取方式对北板蓝根多糖含量和抗氧化活性的影响[J].上海工程技术大学学报,2023,37(02):128-132.

[42] 朱佳敏,顾珂如,赵琳静*,等.天竺葵属植物挥发性成分和生物活性的研究进展[J].食品与发酵工业,2023,49(15):326-335.

[43] 朱佳敏,武艺,赵琳静*,等.猴头菇多糖结构及调节肠道菌群作用研究进展[J].食品与发酵工业,2023,49(14):311-320.

[44] 郝方嘉,张宁,杨娟,等.板蓝根挥发性成分的GC-MS分析及抗菌抗氧化活性研究[J].上海工程技术大学学报,2022,36(01):41-45+104.

[45] 王玉婷,刘霞,彭媛媛,王潇婕,赵琳静*.基于分子对接和药效团的磷脂酶PLA2G1B抑制剂的虚拟筛选[J].上海工程技术大学学报,2022,36(03):295-300.

[46] 杜洪,刘霞,翁涛,潘礼杰,刘月,陈婕,赵琳静*.Box-Behnken优化超声波法提取绞股蓝总皂苷工艺[J].化工生产与技术,2022,28(04):4-6+61.

[47] 郝方嘉,彭媛媛,赵琳静*.基于网络药理学技术研究黄芪-枸杞子药对治疗溃疡性结肠炎的作用机制[J].上海工程技术大学学报,2021,35(04):377-382.

[48] 杨梦文,赵琳静*,顾思怡等.香茅化学成分及药理作用的研究进展[J].中成药, 2020, 42(03): 714-719.

[49] 赵琳静*,王斌,乔妍等.香茅叶挥发油的化学成分及其体外抗氧化活性[J].中成药, 2016, 38(04): 841-845.

[50] 赵琳静*,乔妍,王斌等.柠檬草精油及其在食品工业中的应用[J].食品与发酵工业, 2015, 41(06):246-252.

[51] 赵琳静*,李洪森,吴晓英等.板蓝根抗氧化成分的提取及活性分析[J].食品工业科技, 2014, 35(10): 195-197+201.

[52] 赵琳静*,李洪森,乔妍等.板蓝根多糖的提取与脱蛋白工艺优化[J].食品与发酵工业, 2013, 39(09): 210-213.

[53] 林旭东,高阳,赵思琦,巴合提古丽,牛玉萍,赵琳静*.绞股蓝多糖提取工艺的响应面设计优化[J]. 化工生产与技术, 2013, 20(02):22-24+8.

[54] 胡心怡,李超,高建龙,顾慧越,臧超,李洪森,赵琳静*.龙井茶中总多酚的提取[J].化工生产与技术,2012,19(01):10-11+67.

[55] 赵琳静*,李洪森,陈婷婷等.菊芋菊糖含量的测定[J].化工生产与技术,2010,17(04):43-45+13.

[56] 赵琳静*,燕方龙,宋小平.菊芋菊糖的研究进展[J].食品研究与开发,2008,(04):186-189.

[57] 赵琳静*,宋小平,黎方雅.多糖及其衍生物抗氧化性质的研究进展[J].上海工程技术大学学报,2008,(01):44-47.

[58] 赵琳静*,宋小平.菊芋菊糖的提取与纯化研究[J].上海工程技术大学学报,2007,(04):331-333.

主讲课程“天然药物化学”、“药物化学（双语）”荣获上海市一流课程、上海市重点课程、校精品课程、校课程思政示范课程、校课程思政十佳示范课、校一流课程等荣誉。

校课程思政名师工作室负责人。荣获第五届“匠心筑梦 领航未来”全国高校教师技能创新大赛一等奖、第二届全国本科院校化工类专业教师课程思政能力竞赛一等奖、首届上海市课程思政教学设计展示活动二等奖，以及校“课程思政教学名师”、“优秀主讲教师”、“教学明星”、“优秀共产党员”、“优秀班主任（导师）”、“产学合作教育优秀协调员”等荣誉。 

近五年，指导学生在全国及上海市学科竞赛中获奖 10 余项。