1.  国家自然科学基金委 — 青年基金项目（2021.01~2023.12）
   

2. 上海市教委 — 青年东方学者岗位资助计划（2019~2021）

3. 上海市科委 — 面上项目（2025~2028）
   

   
   

最近三年代表性论文：

Yingjie Chen, Yuanhao Li, Penghai Li, Xin Li, Shuxin Zhao, Zhicheng Zuo*. Catching CRISPR-Cas9 in Action. Journal of Chemical Theory and Computation, 2025, 21(10):5023–5036.

Shuxin Zhao, Jin Liu, and Zhicheng Zuo*. Secondary Conformational Checkpoint in CRISPR-Cas9. Journal of Chemical Theory and Computation, 2024, 20(9):3440-3448.

Xuehua Liu, Zhicheng Zuo, Xiujun Xie, Shan Gao, Songcui Wu, Wenhui Gu, Guangce Wang. SLC24A-mediated calcium exchange as an indispensable component of the diatom cell density-driven signaling pathway. The ISME Journal, 2024, 18(1):wrae039.

Yifan Pan, Zhicheng Zuo, Yucong Jiao, Peiyi Wu. Constructing Lysozyme Protective Layer via Conformational Transition for Aqueous Zn Batteries. Advanced Materials, 2024, 36(29):2314144

Yanan Li, Jian Cao, Chuanxiao Wang, Yiyi Qiao, Jiayu Gao, Linlin Wang, Xiao Zhang, Le Wang, Yuanhao Li, Zhicheng Zuo. Design of fluorescent sensors for the detection of human serum albumin structure employing nitrogen-by modulation of molecular containing heterocycles. Microchemical Journal, 2024, 207:112207.

Niu Zhang and Zhicheng Zuo*. Identification of a Cryptic Binding Site in CRISPR-Cas9 for Targeted Inhibition. Journal of Chemical Information and Modeling, 2023, 63(11):3500-3509.

Nvfan Tang, Qinglan Li, Shiqiang Song*, Xinyan An, Weizhen Li, Zhenlin Jiang*, Zijin Liu, Yong Zhang, Zhicheng Zuo*. Spiderweb-inspired fabrication of 3D MXene hybrid filler with multilayer and multiscale features for multifunctional polydimethylsiloxane composites. Chemical Engineering Journal, 2023, 473:145417.

Minjie Kang, Zhicheng Zuo*, Zhixiang Yin, Jianrong Gu. D1135E-induced Allostery Enhances CRISPR-Cas9 PAM Recognition Specificity. Journal of Chemical Information and Modeling. 2022, 62(12):3057-3066.

Zhicheng Zuo, Kesavan Babu, Chhandosee Ganguly, Ashwini Zolekar, Sydney Newsom, Rakhi Rajan, Yu-Chieh Wang, and Jin Liu. Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-dependent Off-target Effects. The CRISPR Journal, 2022, 5(2): 329-340

1. 2018年 上海市 青年东方学者

1. 计算化学（聚焦以CRISPR-Cas9为代表的核酸酶的催化机理等）

2. 生物物理（聚焦生物大分子结构-动力学-功能关系及其理性设计等）

3. 计算机与人工智能辅助药物设计（聚焦选择性小分子的理性发现与设计等）

招生说明：

具备较强的生化/药化理论知识、对计算化学感兴趣、具有一定的编程能力（如对Python、Linux系统和Shell有一定的了解）；

态度端正、执行力强、不畏困难、能坐得住“冷板凳”。

注：本课题组没有湿实验（wet experiments）。主要研究工具：高性能工作站、高性能计算集群